Have you got enough sleep last night? Or you’re taking yawn and have to stay awake with an extra cup of coffee. No matter how busy you are, good sleep is essential. Today, I will continue to focus on the topic of Epigenetics and sleep.
Along with DNA methylation, histone protein post-translational modifications and chromatin remodeling also play important roles in the molecular regulation of sleep and chronobiology. It is demonstrated that circadian clocks control the expression and deployment of histone-modifying enzymes and corresponding levels of histone marks, since genomic binding distribution of the HMTs, mixed lineage leukemia 3 (MLL3), and related genome-wide profiles of histone H3 lysine lysine 4 trimethylation (H3K4me3), all exhibit circadian rhythms. Conversely, a spectrum of epigenetic factors, including those with HAT, HMT, and HDM histone-modifying and chromatin remodeling enzyme activities, also participate in circadian gene regulation by interacting with core clock proteins. The clinical features of sleep disorder include sleep disordered breathing, insomnia, and sleepiness, and many transcriptional and epigenetic factors are implicated in causing the symptoms, such as the cohesin-loading protein, nipped-B homolog; the core cohesin components, structural maintenance of chromosomes 1A and 3; and HDAC8. These imply that histone and chromatin remodeling may be potential therapeutic targets for sleep disorder and other diseases related to clock genes.
With a lack of sleep linked to health issues, the associated research will continue!