In addition to the histone modifications described in precious post, DNA methylation, as a relatively stable epigenetic mark, is also implicated in mediating the impact of stress.
In nucleus accumbens, chronic social defeat stress is found to increase transcript levels of the de novo Dnmt3a, and increase depression-like behavior after social defeat, while RG108, a DNMT reverses the effect. DNA methylation also regulates corticotropin releasing factor (CRF) in the paraventricular nucleus of the hypothalamus (PVN). In mice that are susceptible to social defeat, CRF is increased with decreased DNA methylation at the Crf promoter, and imipramine can reverses the effect. In addition, it is indicated that aggressive mothers and traumatic stress in rats decrease the expression of Bdnf transcripts III and IV in the HPC with changed DNA methylation patterns. Recent studies also suggest that miRNA is involved in the pathophysiology of depressive disorders.
Early-life exposures to stress or maltreatment may have life-long impact on neuropsychiatric states and behavior by epigenetic mechanisms, and thus results in psychiatric disorders. some evidences demonstrate that prenatal and postnatal stress are involved in altering adult vulnerability to depression via altered DNA methylation at specific genes. More work is needed for understand detailed mechanism.
May has come, why not go to the park for a walk. May alleviate physical and mental fatigue.