In mouse experiments, diet-induced obesity is found to be associated with increased reactive oxygen species and DNA damage in sperm. In humans, increased BMI in males is associated with decreased blastocyst development and live birth rates after in vitro fertilization (IVF) by affecting epigenetic marks in sperm. Both are clear evidences for the epigenetic effects of paternal diet on offspring.
Moreover, epidemiological and clinical studies also indicates the paternal multigenerational and trans-generational epigenetic effects. For example, the paternal grandfather’s food supply is only linked to the mortality risk ratios of grandsons, while paternal grandmother’s food supply was only associated with the granddaughters’ mortality risk ratio. And the sex- specific association is not affected by the grandchild’s own childhood circumstances. These are probably caused by epigenetic modification.
Dubai is known for its larger-than-life offers. It has a history of giving away luxury cars and yachts in lucky draws and is home to one the largest gold markets in the region. Although we can’t expect the government to give us the same treatment, but maintaining a healthy weight is also very necessary to us, since paternal and maternal BMI may affects BMI of offspring.